Esperal Tablet (Disulfiram 250mg)
Esperal Tablet (Disulfiram 250mg) is a specialized medication designed for the treatment of alcohol addiction. It operates by triggering adverse reactions when alcohol is consumed, such as nausea, facial flushing, and headaches. These effects serve as a strong deterrent against the intake of alcohol, assisting individuals in their journey to overcome dependency. This medication is typically used alongside social support and counseling to maximize its effectiveness. Adherence to a doctor’s guidance is crucial while using Esperal Tablet (Disulfiram 250mg) to ensure safe and efficient treatment.
Uses Of Esperal Tablet (Disulfiram 250mg)
- Treatment of chronic alcohol addiction
- Prevention of alcohol relapse
- Support in alcohol detoxification programs
- Adjunct therapy with counseling
- Management of alcohol-related disorders
Treatment of chronic alcohol addiction: Esperal Tablet (Disulfiram 250mg) helps individuals recover from long-term alcohol dependence by inducing adverse reactions when mixed with alcohol.
Prevention of alcohol relapse: By causing unpleasant effects upon alcohol consumption, this medication significantly reduces the chances of relapse.
Support in alcohol detoxification programs: Esperal Tablet (Disulfiram 250mg) is often used as part of broader detox programs to assist in maintaining sobriety.
Adjunct therapy with counseling: Combining this medication with counseling sessions provides added support in the recovery process.
Management of alcohol-related disorders: This medication aids in treating various disorders associated with chronic alcohol consumption.
Safety & Precautions
- Avoid all alcohol-containing products.
- Consult your doctor before use during pregnancy.
- Not recommended for breastfeeding mothers.
- May cause dizziness; avoid driving.
- Use with caution in patients with kidney disease.
- Use with caution in patients with liver disease.
- Do not stop medication suddenly without doctor consultation.
- Follow prescribed dosage strictly.
- Report any persistent side effects to your doctor.
- Not suitable for individuals with certain medical conditions; consult your doctor.
Side Effects
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them.
- Headache
- Fatigue
- Drowsiness
- Metallic taste
- Dizziness
- Sleepiness
- Nausea
- Facial flushing
- Blurred vision
- Mental confusion
- Allergic reactions
- Rash
- Gastrointestinal discomfort
- Weakness
- Depression
FAQ
What is Esperal Tablet (Disulfiram 250mg) used for?
Esperal Tablet (Disulfiram 250mg) is primarily prescribed for the treatment of chronic alcohol addiction. It works by inducing unpleasant effects when alcohol is consumed, thereby deterring individuals from drinking. This medication is often used in combination with social support and counseling to help individuals maintain sobriety.
How should I take Esperal Tablet (Disulfiram 250mg)?
Esperal Tablet (Disulfiram 250mg) should be taken as prescribed by your doctor. It can be taken with or without food. Ensure you take it at a fixed time for consistency. Do not chew, crush, or break the tablet. Complete the full course of treatment without skipping doses. Consult your doctor if you miss a dose.
Are there any products I should avoid while taking Esperal Tablet (Disulfiram 250mg)?
Yes, while on Esperal Tablet (Disulfiram 250mg), you should avoid all products containing alcohol, such as beer, wine, aftershave lotions, mouthwash, vinegar, and some liquid medications. Even small amounts of alcohol can trigger unpleasant effects like nausea, headaches, and facial flushing.
What should I do if I experience side effects from Esperal Tablet (Disulfiram 250mg)?
Most side effects are mild and tend to resolve as your body adjusts to the medication. Common side effects include headache, fatigue, drowsiness, and a metallic taste. If these symptoms persist or worsen, or if you are worried about them, consult your doctor for further advice.
Can I drive while taking Esperal Tablet (Disulfiram 250mg)?
Esperal Tablet (Disulfiram 250mg) may cause dizziness, sleepiness, or affect your vision. These side effects can impair your ability to drive or operate heavy machinery. It is advisable to avoid such activities until you understand how the medication affects you.
Is Esperal Tablet (Disulfiram 250mg) safe during pregnancy and breastfeeding?
Esperal Tablet (Disulfiram 250mg) may be unsafe during pregnancy, as animal studies have shown potential risks. Limited human data suggests it may pass into breast milk and harm the baby. It is essential to consult your doctor before using this medication if you are pregnant or breastfeeding.
Additional Information
Dosages: What Are Dosages of Disulfiram?
Disulfiram, marketed under the brand name Antabuse, is prescribed for managing alcoholism by deterring alcohol consumption through unpleasant reactions. Below are detailed dosage guidelines:
| Form | Dosage |
|---|---|
| Tablet | 250mg, 500mg |
Adult Dosage for Alcoholism
- Only administer after the patient has abstained from ethanol for at least 12 hours.
- 500 mg orally once daily initially for 1-2 weeks; not to exceed 500 mg/day.
- Maintenance: 250 mg orally once daily (125-500 mg range); continue therapy until a basis for self-control has been established; patient may continue to take drug therapy for months or even years.
The dosage may need to be adjusted based on individual needs and response to therapy.
Drug Interactions: What Other Drugs Interact with Disulfiram?
Disulfiram can interact with various medications, leading to increased risk of side effects or reduced efficacy. Notable interactions include:
Severe Interactions
- Benznidazole
- Dronabinol
- Eliglustat
- Ritonavir
Serious Interactions
- Carbamazepine
- Ethonal (ethanol)
- Lonafarnib
- Metronidazole
- Pexidartinib
- Selinexor
- Tinidazole
- Tipranavir
Moderate Interactions (at least 30 other drugs)
Some examples include commonly prescribed medications, and patients should always consult with their healthcare provider before beginning any new medication while on Disulfiram.
Minor Interactions (at least 31 other drugs)
These interactions may not be clinically significant but should still be discussed with a healthcare provider.
For a comprehensive list, consult the RxList Drug Interaction Checker or your medical provider. It is crucial to keep an updated list of all medications and share it with your healthcare team to avoid potential interactions.
Dosage Considerations: Should Be Given as Follows
When prescribing Disulfiram, physicians should consider the following:
- Administer only after ethanol abstention for at least 12 hours.
- Initial dose of 500 mg daily for 1-2 weeks, not exceeding 500 mg daily.
- Maintenance dose ranges from 125 mg to 500 mg daily.
- Continuous monitoring of patient’s liver function is necessary.
| Indication | Dosage | Duration |
|---|---|---|
| Alcoholism (Initial) | 500 mg once daily | 1-2 weeks |
| Alcoholism (Maintenance) | 250 mg once daily (range: 125-500 mg) | As long as necessary to establish self-control |
Reference and Source Citations
| Information Category | Source |
|---|---|
| Drug Interactions | RxList Drug Interaction Checker |
| Dosage Guidelines | FDA |
| Side Effects & Precautions | FDA |
Always consult with a healthcare professional for medical advice and to ensure the information is applicable to your personal health circumstances. For any adverse effects or serious concerns, contacting the FDA at 1-800-FDA-1088 is recommended.
