Acivir 800 DT Tablet (Acyclovir 800mg)
Acivir 800 DT Tablet (Acyclovir 800mg) is a potent antiviral medication that effectively combats viral infections such as herpes labialis, herpes simplex, shingles, genital herpes infection, and chickenpox. By hindering the multiplication of viruses in human cells, Acivir 800 DT Tablet aids in clearing these infections. It should be taken as per the prescribed dosage and duration by your doctor. Dissolve it in a glass of water before consumption, ensuring maximum effectiveness and convenience.
Uses Of ‘Acivir 800 DT Tablet (Acyclovir 800mg)’
- Treatment of Herpes Simplex Virus Infections
- Treatment of Chickenpox
- Treatment of Herpes labialis
- Treatment of Shingles
- Treatment of Genital herpes infection
Treatment of Herpes Simplex Virus Infections: Acivir 800 DT Tablet (Acyclovir 800mg) slows the growth and spread of the herpes virus, providing relief from symptoms like tingling, pain, burning, and itching. It aids in the rapid healing of sores, though it does not cure herpes or prevent its transmission.
Treatment of Chickenpox: Acivir 800 DT Tablet (Acyclovir 800mg) is most effective for treating chickenpox if started within 24 to 48 hours after rash onset. It helps reduce the severity and spread of the virus while promoting faster recovery and preventing complications.
Treatment of Herpes labialis: Known commonly as cold sores, herpes labialis manifests as painful blisters or sores on the lips. Acivir 800 DT Tablet (Acyclovir 800mg) speeds up the healing process and prevents recurrent outbreaks, providing significant relief from accompanying symptoms.
Treatment of Shingles: Acivir 800 DT Tablet (Acyclovir 800mg) shortens the duration and lessen the severity of shingles, a painful viral infection characterized by rashes. Early treatment soon after rash appearance maximizes its effectiveness.
Treatment of Genital herpes infection: Genital herpes causes genital pain and sores, affecting both men and women. Acivir 800 DT Tablet (Acyclovir 800mg) efficiently treats these symptoms and prevents the virus from multiplying, ensuring relief and minimizing recurrent episodes.
Safety & Precautions
- Consult your doctor before taking Acivir 800 DT Tablet (Acyclovir 800mg).
- Do not skip doses and complete the full course of treatment.
- Dissolve the tablet in a glass of water before taking.
- Can be taken with or without food, preferably at a fixed time.
- Drink plenty of water to prevent dehydration and kidney damage.
- Inform your doctor if you experience persistent side effects.
- Consult your doctor if you are pregnant, planning to conceive, or breastfeeding.
- Use cautiously in patients with kidney disease, dose adjustment may be required.
- Use cautiously in patients with liver disease, dose adjustment may be required.
- It is unknown if alcohol interacts with Acivir 800 DT Tablet (Acyclovir 800mg). Consult your doctor.
Side Effects
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them.
- Headache
- Dizziness
- Vomiting
- Nausea
- Fatigue
- Fever
- Stomach pain
- Diarrhea
- Skin rash
- Photophobia
FAQ
1. How should I take Acivir 800 DT Tablet (Acyclovir 800mg)?
You should take Acivir 800 DT Tablet (Acyclovir 800mg) as directed by your doctor. Dissolve the tablet in a glass of water before consumption. It can be taken with or without food, preferably at a fixed time each day to maintain a consistent level in your bloodstream. Do not skip doses, and complete the full course of treatment even if you feel better.
2. What should I do if I miss a dose of Acivir 800 DT Tablet (Acyclovir 800mg)?
If you miss a dose of Acivir 800 DT Tablet (Acyclovir 800mg), take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Avoid taking a double dose to make up for the missed one as it may lead to side effects.
3. Are there any special precautions I should take while using Acivir 800 DT Tablet (Acyclovir 800mg)?
Yes, there are some precautions you should take. Ensure you drink plenty of water while on treatment to prevent dehydration and kidney damage. Avoid skipping doses and complete the prescribed treatment course. If you experience persistent side effects or have underlying health conditions such as kidney or liver disease, consult your doctor for appropriate dose adjustments and monitoring.
4. Can I take Acivir 800 DT Tablet (Acyclovir 800mg) during pregnancy and breastfeeding?
Acivir 800 DT Tablet (Acyclovir 800mg) is generally considered safe during pregnancy and breastfeeding if prescribed by your doctor. Animal studies have shown low or no adverse effects on the developing baby, and human studies suggest the drug does not pass into breastmilk in significant amounts. However, always consult your healthcare provider before starting any medication during pregnancy or breastfeeding.
5. How does Acivir 800 DT Tablet (Acyclovir 800mg) work?
Acivir 800 DT Tablet (Acyclovir 800mg) is an antiviral medication that works by preventing the multiplication of viruses in human cells. This action stops the virus from producing new viruses, ultimately leading to the clearing of your infection and providing relief from associated symptoms such as pain, itching, and burning sensations.
6. Can I drive while taking Acivir 800 DT Tablet (Acyclovir 800mg)?
Acivir 800 DT Tablet (Acyclovir 800mg) does not usually affect your ability to drive. However, if you experience side effects such as dizziness or fatigue, it is advisable to avoid driving or operating heavy machinery until you feel better. Always pay attention to how your body responds to the medication and consult your doctor if you have any concerns.
Dosages of Acyclovir
Acyclovir is prescribed in various forms and strengths, tailored to treat different herpes-related conditions. Here we provide detailed dosages for several target conditions:
Dosages Based on Forms and Strengths
| Form | Strength |
|---|---|
| Injectable solution | 50 mg/mL |
| Oral suspension | 200 mg/5mL |
| Powder for injection | 500 mg/vial, 1 g/vial |
| Tablet | 400 mg, 800 mg |
| Capsule | 200 mg |
Dosage Considerations: Should be Given as Follows
Genital Herpes
- Initial treatment: 200 mg orally every 4 hours while awake (5 times daily) for 10 days or 400 mg orally every 8 hours for 7-10 days
- Intermittent treatment for recurrence: 200 mg orally every 4 hours while awake (5 times daily) for 5 days; initiate at the earliest sign or symptom of recurrence
- Chronic suppression for recurrence: 400 mg orally every 12 hours for up to 12 months; alternatively, 200 mg 3-5 times daily
Herpes Simplex Virus Encephalitis
- Adults: 10-15 mg/kg intravenously (IV) every 8 hours for 10 days; up to 14-21 days reported
- Children 3 months to 12 years: 20 mg/kg IV every 8 hours for 10 days; up to 14-21 days reported
- Children over 12 years: 10-15 mg/kg IV every 8 hours for 14-21 days
- In obese patients, use ideal body weight (IBW)
Mucocutaneous Herpes Simplex Virus Infection in Immunocompromised Patients
- Adult Intravenous (IV): 5 mg/kg every 8 hours for 7 days; dosing up to 14 days reported
- In obese patients, ideal body weight (IBW)
- Oral (off-label): 400 mg every 4 hours while awake (5 times daily) for 7 days
- Pediatric Younger than 12 years: 10 mg/kg intravenously (IV) every 8 hours for 7 days
- Older than 12 years: 5-10 mg/kg/day IV divided every 8 hours for 5-7 days; up to 14 days reported
Herpes Zoster (Shingles)
- Adult Acute Treatment: 800 mg orally every 4 hours while awake (5 times daily) for 7-10 days
- Immunocompromised patients: 10 mg/kg IV every 8 hours for 7 days
- In obese patients, use ideal body weight (IBW)
- CrCl 25-50 mL/min: Full recommended IV dose every 12 hours
- CrCl 10-25 mL/min: Full recommended IV dose once daily
- CrCl 0-10 mL/min: 50% of recommended IV dose once daily
- Pediatric Younger than 12 years (immunocompromised): 20 mg/kg IV every 8 hours for 7 days
- Older than 12 years (immunocompetent): 800 mg orally every 4 hours while awake (5 times daily) for 7-10 days
- Older than 12 years (immunocompromised): 30 mg/kg/day IV divided every 8 hours for 7-10 days
Varicella-Zoster (Chickenpox)
- Adult Greater than 40 kg (immunocompetent): 800 mg orally every 6 hours for 5 days
- Immunocompromised patients: 10-15 mg/kg IV every 8 hours for 7-10 days
- In obese patients, use ideal body weight (IBW)
- Pediatric Children 2 years and older and less than 40 kg: 20 mg/kg/dose orally every 6 hours for 5 days; not to exceed 800 mg/dose
- In obese patients, use ideal body weight (IBW)
- Greater than 40 kg: 800 mg orally every 6 hours for 5 days
- Immunocompromised patients Younger than 12 years: 20 mg/kg/dose intravenously (IV) every 8 hours for 7 days
- Older than 12 years: 10 mg/kg/dose IV every 8 hours for 7 days
Dosing Modifications
Adjustments Based on Renal Clearance and Normal Dosage Regimen
- 200 mg every 4 hours 0-10 mL/min/1.73 m²: 200 mg every 12 hours
- Greater than 10 mL/min/1.73 m²: 200 mg every 4 hours (five times daily)
- 400 mg every 12 hours 0-10 mL/min/1.73 m²: 200 mg every 12 hours
- Greater than 10 mL/min/1.73 m²: 400 mg every 12 hours
- 800 mg every 4 hours 0-10 mL/min/1.73 m²: 800 mg every 12 hours
- 10-25 mL/min/1.73 m²: 800 mg every 8 hours
- Greater than 25 mL/min/1.73 m²: 800 mg every 4 hours (five times daily)
Adjustments Based on Dosage Form
| Renal Impairment | Adjustment |
|---|---|
| CrCl 25-50 mL/min/1.73 m² (IV) | Give recommended dose every 12 hours |
| CrCl 10-25 mL/min/1.73 m² (IV) | Give recommended dose every 24 hours |
| CrCl less than 10 mL/min/1.73 m² (IV) | Give 50% of recommended dose every 24 hours |
| CrCl less than 10 mL/min/1.73 m² (Oral) | Decrease to 200 mg every 12 hours |
| CrCl 10-25 mL/min/1.73 m² (800 mg every 4 hours Normal Oral Dosage) | Decrease to 800 mg every 8 hours |
| CrCl less than 10 mL/min/1.73 m² (800 mg every 4 hours Normal Oral Dosage) | Decrease to 800 mg every 12 hours |
Drug Interactions and Their Severity
Acyclovir’s interactions with other drugs can be serious, moderate, or mild. Understanding these interactions ensures optimal efficacy and minimizes risks.
Severe Interactions
- No severe interactions reported.
Serious Interactions
- Amphotericin B deoxycholate
- bacitracin
- cidofovir
- neomycin PO oral
- probenecid
- talimogene laherparepvec
Moderate and Mild Interactions
- Acyclovir has moderate interactions with at least 28 different drugs and mild interactions with at least 65 different drugs.
- Always consult your healthcare provider to manage and understand drug interactions effectively.
Additional Information
Acyclovir, sold under the brand name Zovirax among others, is an antiviral drug known for its efficiency in treating herpes infections. Besides cold sores and genital herpes, it also manages conditions like shingles, chickenpox, and herpes simplex encephalitis. Below, we provide further insights into its uses, and recent studies supporting its efficacy.
Topical Use for Herpes Labialis
Acyclovir can be applied topically at the onset of cold sores to reduce healing time and pain. A study by Spruance et al. (2003) reported that 5% topical acyclovir reduced healing time by approximately 1.5 days compared to a placebo.
Mechanism of Action
Acyclovir works by inhibiting herpes virus DNA replication. Once it enters the infected cells, it gets phosphorylated by viral thymidine kinase to the monophosphate form. Eventually, it competes with deoxyguanosine triphosphate, integrating into viral DNA and causing chain termination.
Alternative Treatments
- Valacyclovir (Valtrex) is an alternative to acyclovir. It is a prodrug that converts to acyclovir in the body and has demonstrated higher oral bioavailability.
- Famciclovir (Famvir) is another alternative, used particularly for herpes zoster and genital herpes.
In conclusion, Acyclovir stands as a versatile antiviral medication, impacting diverse forms of herpes infections. Adhering to the dosage and addressing potential drug interactions effectively maximizes its benefits. While it doesn’t cure herpes, it offers significant symptom relief and suppression, improving the quality of life for many sufferers.
References:
- Spruance, S. L., et al. (2003). “Topical Acyclovir Therapy of Herpes Simplex Labialis: A Randomized, Double-Blind, Vehicle-Controlled, Multicenter Trial.” JAMA.
- “Acyclovir.” Drugs.com. Available at: https://www.drugs.com/acyclovir.html
- “Acyclovir.” MedlinePlus. Available at: https://medlineplus.gov/druginfo/meds/a682731.html
